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. 2020 Apr 16;10:475. doi: 10.3389/fonc.2020.00475

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Copyright © 2020 Li, Liu, Han, Tang and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Main delivery routes of oncolytic virotherapy. (a) Intravenous delivery: When oncolytic viruses are injected into the peripheral vein, they reach tumor lesions in non-specific organs and systems through the circulation system. (b) Intratumoral delivery: When oncolytic viruses are injected into tumors, they have a direct therapeutic effect on the lesion. (c) Intraperitoneal delivery: When oncolytic viruses are injected into the peritoneal cavity, they will be absorbed into the veins of the peritoneum and then reach tumor lesions of some organs or systems through the circulation system, or they will diffuse directly to tumor lesions in the peritoneal cavity.