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. 2020 Apr 16;11:703. doi: 10.3389/fmicb.2020.00703

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Copyright © 2020 Tan and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing TRIM21 alleviates the severity of HSV epithelial keratitis. (A) The protein (left) and mRNA (right) levels of TRIM21 in corneas were assessed to confirm the transfection efficiency of siRNA before establishing HSV epithelial keratitis models. (B) HSV epithelial keratitis clinical scores at 3 dpi. n = 8 per time point. (C) Representative photographs of corneas from each group of mice at 3 dpi corresponding to (D) histopathology results. Magnification: 400×.