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. 2020 Apr 16;11:703. doi: 10.3389/fmicb.2020.00703

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Copyright © 2020 Tan and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRIM21 inhibited STING-IRF3 signaling in HSV-1-infected HCE cells. (A) The protein (left) and mRNA levels (right) of TRIM21 in HCE cells were assessed to confirm the transfection efficiency of lentivirus and siRNA before HSV-1 infection. (B) The mRNA level of IFN-β in each group was examined after HSV-1 infection 12 h. (C) The protein expression levels of TRIM21, STING, phosphorylation of IRF3, and IRF3 were examined after HSV-1 infection 12 h. (D) HCE cells pretreated with both siRNA-TRIM21 and siRNA-STING. After HSV-1 infection 12 h, qPCR detected the production of IFN-β. Data are shown as mean ± SD of three independent experiments. ^∗P < 0.05.