Table 2.

Summary of papers reporting on CBF measurements and autoregulation in children with severe TBI.

References	Method	n	Age	CBF (ml/100 g/min)/autoregulation	CBF measurement time after TBI	TBI Severity
Kasoff et al. (30)	Xe injection	10	9 month−12 year		Hours-2 months	GCS <8
Muizelaar et al. (32)	Xe133 inhalation/inj	32	3–18 year	Good outcome 48.8 ± 24.8	Within 72 h	GCS <7
				Poor outcome 34.7 ± 9.9
Sharples et al. (33)	10% NO	17	2–16 year	Low CBF in patients with worse outcome	Within 24 h	GCS <8
Skippen et al. (15)	Xe-CT	23	3 month−16 year	Mean 49.6 ± 14.6		GCS <8
Adelson et al. (14)	Xe-CT	30	0–8	Mean 55	Admission—day 9	GCS <8
				Poor outcome 9.9
				Good outcome 43.9
Adelson et al. (34)	Xe-CT	95		Mean 32	Admission—day 9	GCS <8
				Good outcome 46
				Poor outcome 18
Sharples et al. (13)	10% NO	21	2–16 year	Day 1 40–60 ml/100 g/ml	6–57 h	GCS <8
Muizelaar et al. (35)	Xe133-phenylephrine	26	8–18 year	No correlation between autoregulation and outcome	Before and after 36 h	GCS <7
Vivalala (36)	TCD	28	5–15 year	Impaired autoregulation-worse 6 m outcome	Within 72 h	GCS <9
Freeman et al. (38)	TCD-phenylephrine	37	8 month−16	Impaired autoregulation in <4 year	Within 72 h	GCS <13
Chaiwat et al. (37)	TCD	36	8 month−16 year	Impaired autoregulation-worse outcome	Within 72 h	GCS <9
Brady et al. (40)	PRx	21	3 month−15 year	PRx associated with survival		GCS <8
Young et al. (41)	PRx	12	3 month−13 year	PRx correlates with 6 months outcome		GCS <8
Lewis et al. (42)	PRx	36	6 month−16 year	PRx correlates with outcome		GCS <8