Figure 2.

Simplified schematic representation of NONO protein function. The DBHS proteins SFPQ (S) and NONO (N) are represented as simple green and orange spheres respectively. (1) SFPQ and NONO can sequester transcription factors away from target promoters, (2) act as co‐repressors at target promoters and (3) in complex with repressors stimulate epigenetic silencing. (4) Both SFPQ and NONO are associated with co‐activation of transcription through (5) elongation up to termination. (6) SFPQ and NONO also remain associated with nascent mRNA to facilitate co‐transcriptional processing, (7) messenger ribonucleoprotein (mRNP) export and (8) cytosolic trafficking. (9,10) By virtue of their involvement in paraspeckle formation and integrity, SFPQ and NONO can facilitate nuclear RNA retention. (11) SFPQ, NONO and PSPC1 are also involved in double‐stranded break repair. (12) TFE3‐NONO rearrangement