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. 2020 Mar 9;24(8):4659–4667. doi: 10.1111/jcmm.15130

Figure 4.

Figure 4

CD137 signalling induced Th17 cell differentiation and atherosclerosis through modulating IL‐6 of ECs‐derived exosomes in ApoE−/− mice. A, Representative en face Oil red O staining of the entire aortas of the five groups of ApoE−/− mice. B, Representative cross‐sectional images of the aortic plaque of the five groups of ApoE−/− mice. The cross‐sectional slice of the aorta (yellow box area), 2 mm above the aortic valve (white arrow). The expression of Th17 cells was stained by immunofluorescence analysis. Bar: 200 μm. C, Quantification of the en face lesion areas of the entire aortas of the five groups of ApoE−/− mice (*P < .05, n = 3). D, Quantification of the cross‐sectional plaque areas of the five group of ApoE−/− mice (*P < .05, n = 3)