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CD137 signalling regulated IL‐6 expression in ECs through Akt and NF‐КB pathway. A, CD137‐provoked up‐regulation of IL‐6 is blocked by Akt inhibitor (*P < .05, n = 5). B, CD137‐provoked up‐regulation of IL‐6 is blocked by NF‐КB inhibitor (*P < .05, n = 5). C, CD137 increased expression of Akt at serine 473 after 30 min of incubation, whereas attenuated by Akt inhibitor (*P < .05, n = 3). D, CD137‐induced expression of nuclear NF‐КB p65 is attenuated by Akt inhibitor (*P < .05, n = 3)
