Table 2.
Effect of MiRNA detected in NPCE cell line‐derived EVs in the regulation of WNT/β‐catenin signalling pathway
| miRNA | Wnt‐signaling target | Inhibits/activates Wnt signaling pathway | References |
|---|---|---|---|
| miR‐21 | DKK2, TGFβR2, Wnt1 | Activates or Inhibits | 51, 54, 55 |
| miR‐638 | FZD7 | Inhibits | 56 |
| miR‐100 | DKK1, ZNRF3 | Activates | 57 |
| miR‐125 | DKK3, ZNRF3, RNF43, APC2 | Activates | 57 |
| miR‐23a | FZD5 | Inhibits | 58 |
| miR‐29a | sFRP‐2, DKK1 | Activates | 59 |
| miR‐15b | Axin2 | Activates | 60 |
| miR‐29b | TCF7L2, BCL9L, SNAI1 | Inhibits | 61 |
| miR‐146a | ZNRF3 | Activates | 62 |
| miR‐20a/19b | E2F1, HIPK1 | Activates | 63 |
| miR‐130a | RUNX3 | Activates | 64 |
| miR‐27a‐3p | SFRP1 | Activates | 65 |
| miR‐365b | Wnt5a | Inhibits | 66 |
| miR‐25 | β‐catenin | Inhibits | 67 |
| miR‐181a | WIF1 | Activates | 68 |