Table 1.
Upregulated or downregulated KEGG pathways in myasthenia gravis (MG).
| Name | Main_Category | Sub_Category | NES | P-value |
|---|---|---|---|---|
| Upregulated pathways in MG(+) cases in type AB thymoma | ||||
| hsa00190_Oxidative_phosphorylation | 1. Metabolism | 1.2. Energy metabolism | 2,57 | 0,0048 |
| hsa05012_Parkinson_disease | 6. Human Diseases | 6.4. Neurodegenerative diseases | 2,45 | 0,0048 |
| hsa05010_Alzheimer_disease | 6. Human Diseases | 6.4. Neurodegenerative diseases | 1,985 | 0,0048 |
| hsa05016_Huntington_disease | 6. Human Diseases | 6.4. Neurodegenerative diseases | 1,985 | 0,0048 |
| hsa04932_Non-alcoholic_fatty_liver_disease_(NAFLD) | 6. Human Diseases | 6.7. Endocrine and metabolic diseases | 1,875 | 0,0048 |
| hsa04714_Thermogenesis | 5. Organismal Systems | 5.10. Environmental adaptation | 2,02 | 0,0050 |
| hsa03050_Proteasome | 2. Genetic Information Processing | 2.3. Folding, sorting and degradation | 2,03 | 0,0124 |
| hsa04723_Retrograde_endocannabinoid_signaling | 5. Organismal Systems | 5.6. Nervous system | 1,51 | 0,0221 |
| hsa03010_Ribosome | 2. Genetic Information Processing | 2.2. Translation | 2,47 | 0,0247 |
| hsa04260_Cardiac_muscle_contraction | 5. Organismal Systems | 5.3. Circulatory system | 1,7 | 0,0267 |
| Downregulated pathways in MG(+) cases in type AB thymoma | ||||
| hsa04520_Adherens_junction | 4. Cellular Processes | 4.3. Cellular community - eukaryotes | −1,905 | 0,0048 |
| hsa04933_AGE-RAGE_signaling_pathway_in_diabetic_complications | 6. Human Diseases | 6.7. Endocrine and metabolic diseases | −1,84 | 0,0061 |
| hsa04350_TGF-beta_signaling_pathway | 3. Environmental Information Processing | 3.2. Signal transduction | −1,745 | 0,0065 |
| hsa05205_Proteoglycans_in_cancer | 6. Human Diseases | 6.1. Cancers: Overview | −1,65 | 0,0149 |
| hsa05140_Leishmaniasis | 6. Human Diseases | 6.10. Infectious diseases: Parasitic | −1,695 | 0,0178 |
| hsa05206_MicroRNAs_in_cancer | 6. Human Diseases | 6.1. Cancers: Overview | −1,58 | 0,0226 |
| hsa05145_Toxoplasmosis | 6. Human Diseases | 6.10. Infectious diseases: Parasitic | −1,66 | 0,0248 |
| hsa04062_Chemokine_signaling_pathway | 5. Organismal Systems | 5.1. Immune system | −1,485 | 0,0251 |
| hsa05200_Pathways_in_cancer | 6. Human Diseases | 6.1. Cancers: Overview | −1,445 | 0,0254 |
| Upregulated pathways in MG(+) cases in type B2 thymoma | ||||
| hsa04740_Olfactory_transduction | 5. Organismal Systems | 5.7. Sensory system | 1,92 | 0,0130 |
| Downregulated pathways in MG(+) cases in type B2 thymoma | ||||
| hsa04141_Protein_processing_in_endoplasmic_reticulum | 2. Genetic Information Processing | 2.3. Folding, sorting and degradation | −1,88 | 0,0119 |
| hsa01100_Metabolic_pathways | 1. Metabolism | 1.0 Global and overview maps | −1,36 | 0,0126 |
| hsa03030_DNA_replication | 2. Genetic Information Processing | 2.4. Replication and repair | −2,07 | 0,0137 |
| hsa00190_Oxidative_phosphorylation | 1. Metabolism | 1.2. Energy metabolism | −1,725 | 0,0148 |
| hsa05012_Parkinson_disease | 6. Human Diseases | 6.4. Neurodegenerative diseases | −1,66 | 0,0204 |
| hsa05016_Huntington_disease | 6. Human Diseases | 6.4. Neurodegenerative diseases | −1,56 | 0,0218 |
| hsa00240_Pyrimidine_metabolism | 1. Metabolism | 1.4. Nucleotide metabolism | −1,645 | 0,0246 |
NES, normalized enrichment score; P-value, adjusted P-value; Both NES and P-value are mean score (or value) between that of TdT-low and -high groups.