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. 2020 Apr 16;11:277. doi: 10.3389/fphys.2020.00277

FIGURE 5.

FIGURE 5

Effects of short-chain fatty acids (SFCAs) in mitochondrial ROS in rat aortic endothelial cells (RAECs). Mitochondrial ROS (A) in the presence of the antioxidant mitoQ (0.1 μM) during AngII incubation in RAECs incubated with butyrate (5 mM), acetate (10 mM), or propionate (10 mM). In some experiments (B), cells were coincubated with GLPG0974 (GLPG, 0.1 μM) or β-hydroxybutyrate (SHB, 5 mM) for 24 h, and in the last 6 h in the absence (control) or presence of AngII (1 μM). Results are shown as mean ± SEM (six to eight). *P < 0.05 vs. ctrl; #P < 0.05 vs. AngII; +P < 0.05 vs. AngII + SFCA group.