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. 2020 Apr 16;11:162. doi: 10.3389/fendo.2020.00162

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Copyright © 2020 Di, Wang, Hu, Yan, Ma, Li, Li and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of melatonin administration on survival, cardiac dysfunction and inflammation after LPS insult. (A) 30 mg/kg LPS was given to mice to assess the effects of LPS on survival rate. The mice survival rate was evaluated using Kaplan-Meier curves (n = 15). (B) Representative M-mode echocardiograms from mice in each group and quantitative analysis of the LVEF, FS, LVID; d, LVID; s. (C) Representative bands of pNF-κB, IκBα and Tubulin, quantitative analysis of pNF-κB, IκBα expression and serum IL-6, TNF-α levels. n = 6 **P < 0.05 vs. the control group, ^##P < 0.05 vs. the LPS group. Mel, melatonin.