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. 2020 Apr 16;11:162. doi: 10.3389/fendo.2020.00162

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Copyright © 2020 Di, Wang, Hu, Yan, Ma, Li, Li and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Compound C treatment exacerbated LPS-induced injury and impaired melatonin-induced cardiac protection. (A) Representative M-mode echocardiograms from mice in each group and quantitative analysis of mice LVEF, FS, LVID; d, LVID; s. (B) Representative bands of pNF-κB and IκBα, and quantitative analysis of pNF-κB, IκBα expressions and serum IL-6, TNF-α levels. n = 6. **P < 0.05 vs. the LPS group, ^##P < 0.05 vs. the LPS + Compound C group, ^$$P < 0.05 vs. the LPS + melatonin group. Mel, melatonin.