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. 2020 Apr 16;11:162. doi: 10.3389/fendo.2020.00162

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Copyright © 2020 Di, Wang, Hu, Yan, Ma, Li, Li and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Autophagy inhibition increased myocardial apoptosis, and autophagy activation decreased Compound C induced myocardial apoptosis. (A) Representative images of TUNEL staining and quantitative analysis of the apoptosis ratio. (B) Representative bands of western blot and quantitative analysis of pmTOR phosphorylation levels, p62 expression, LC3B-II/LC3B-I ratio, Bcl-2 expression and Bax expression. n = 6, **P < 0.05 vs. the LPS + melatonin group, ^##P < 0.05 vs. the LPS + Compound C group. Mel, melatonin; C, Compound C; Rapa, rapamycin.