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. 2019 Dec 31;52(2):622–633. doi: 10.4143/crt.2019.593

Fig. 3.

Fig. 3.

Chemokine (C-X-C motif) ligand 13 (CXCL-13) promotes colorectal cancer cells resistance to 5-fluorouracil (5-Fu) through autocrine mechanism. (A, B) Viability of DLD-1 cells or HCT116 cells treated with different concentrations of 5-Fu for 3 days after pretreatment with 10 ng/mL of CXCL-13 for 6 hours. (C, D) Viability of DLD-1 5-Fu resistant (5-FuR) cells or HCT116 5-FuR cells treated with different concentrations of 5-Fu for 3 days after pretreatment with a control IgG or a CXCL-13 neutralizing antibody (5 μg/mL) for 6 hours. Data from three independent experiments were tested in triplicate. *p < 0.05, **p < 0.01, ***p < 0.001 by Student’s t test or one-way ANOVA.