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. 2020 Apr 16;11:425. doi: 10.3389/fphar.2020.00425

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Copyright © 2020 Zhou, Ai, Li, You, Wu, Li, Hu and Ba

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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N-butanol extract of Taohe-Chengqi decoction (NE-THCQ) inhibited extracellular matrix (ECM) accumulation and epithelial-mesenchymal transformation (EMT) in the kidneys of unilateral ureteral obstruction (UUO) rats. The representative images and statistical graph of immunofluorescence staining for COL-I, COL-III, E-cadherin and α-SMA (400 ×). Bar = 20 μm. Data were presented as mean standard deviation (SD), n = 6 rats per group. For the NE-THCQ group vs. the UUO group on the 7th day, * indicates P < 0.05, ** indicates P < 0.01. For the NE THCQ group vs. the UUO group on the 14th day, ^## indicates P < 0.01.