TABLE 5.

Number of genes including at least 1 indel per impact category.

	Impact category1	Protein-coding genes	Protein-coding genes (excl. protein families)
old_rep1	High	367	56
	Moderate	85	27
	Low	1	0
old_rep2	High	397	60
	Moderate	95	27
	Low	0	0

¹Impact category groups were defined by Ensembl as follows: HIGH – The variant is assumed to have high (disruptive) impact in the protein, probably causing protein truncation, loss of function or triggering nonsense mediated decay; MODERATE – A non-disruptive variant that might change protein effectiveness; LOW – Assumed to be mostly harmless or unlikely to change protein behavior (https://m.ensembl.org/info/genome/variation/prediction/predicted_data.html).