Table 4.

The novelty of the positive signals of DILI.

Drug ID	Drugs	Literature (PUBMED)a		Literature (CNKI/Wanfang)		SPCsb
		Adults	Children	Adults	Children
1	Fluconazole	Yes	Yes	Yes	No	Yesc
2	Omeprazole	Yes	Yes	Yes	No	Yes
3	Sulfamethoxazole	Yes	Yes	Yes	Yes	Yes
4	Vancomycin	Yes	Yes	Yes	Yes	Yes
5	G-CSF	No	No	No	No	Yes
6	Acetaminophen	Yes	Yes	Yes	Yes	Yes
7	Nifedipine	Yes	No	Yes	No	Yes
8	Fusidine	Yes	No	Yes	No	Yes
9	Oseltamivir	Yes	No	Yes	No	Yes
10	Nystatin	No	No	No	No	No
11	Meropenem	Yes	Yes	Yes	Yes	Yes

^aLiterature reviewed: (1) PUBMED: https://pubmed.ncbi.nlm.nih.gov; (2) Wanfang: http://www.wanfangdata.com.cn/index.html); (3) CNKI: https://www.cnki.net.

^bSPCs reviewed: (1) Micromedex: https://www.ibm.com/watson-health/learn/micromedex); (2) FDA website: https://www.fda.gov/; (3) Drug instructions.

^cYes = drug–DILI association was documented.

DILI, drug–induced liver injury; G-CSF, granu1ocyte colony-stimulating factor; SPC, summary of product characteristics.