Fig. 1.

Cancer Associated Fibroblasts in the Tumor Microenvironment and therapy response A) CAFs play a central role in the TME by interacting with cancer cells and immune cells and affecting key processes such as B) immunomodulation, metabolism, ECM remodeling, autophagy, epithelial-mesenchymal transition and treatment resistance to e.g. C) radiation therapy. Different factors expressed by CAFs after RT mediate subsequent fibrosis, EMT/invasion and treatment resistance [126], [131], [132], [133].