Table 1.

Roles of Sirt4 in tumorigenesis.

Phenotype	Cancer types	Role of Sirt4	References
Sirt4 downregulation	Acute myeloid leukemia, Burkitt lymphoma, and lung, colorectal, gastric, liver, lung, endometrial, pancreatic, ovarian, prostate, and renal cancers	Cancer suppression: inhibition of tumor proliferation, invasion, and migration	(4, 33–35, 37–46)
Sirt4 over-expression	Esophageal cancer, hepatocarcinoma (HepG2 cells)	Cancer promotion: enhanced cancer cell survival rate in “extreme” DNA-damaging conditios	(4, 47, 48)