Table 2.

Issues to be addressed in order to label a patient as “resistant”

1. Correct diagnosis

2. Disorder not secondary to an organic disorder

3. Poor response to treatment not due to somatic or mental comorbidity

4. Poor response to treatment not due to a somatic condition that might not constitute a disorder by itself (e.g., genetic factors, smoking, alcohol use, gender, race, etc.)

5. Failure of therapy not due to nontolerability

6. Patient complies with recommended treatment and poor response not a consequence of lack of adherence