Table 2.

Tangential Flow Filtration Optimization Parameters

Phase	System	Feed (kg/m2)	Flux (LMHa)	Crossflow (%)	TMP Maxb (Bar)
Optimization	ÄKTA crossflow	10–70	10	64	0.06
Optimization	Cogent M	50–120	24–100	88–90	0.2–0.5
First scale-up run TFF1	Mobius	42	14	88	0.1
First scale-up run TFF2	Cogent M	8.4	12	94	0.2
Second scale-up run TFF1	Mobius	43	13	89	0.2
Second scale-up run TFF2	Cogent M	8.6	8.4–12	94–97	NA

NA, not applicable.

^aLiters per square meter per hour.

^bMaximum transmembrane pressure during the run.