Barnes 2000.

Methods	sealed envelopes, randomised number sequence, 3 lost to FU
Participants	Caucasian > 45
Interventions	trabeculectomy +/‐ beta radiation
Outcomes	IOP < 21 = success (+/‐ medication) mean IOP
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"The patients randomly received or did not receive a dose of beta radiation" Page 259, last paragraph
Allocation concealment (selection bias)	Unclear risk	‐
Blinding (performance bias and detection bias) All outcomes	Low risk	“There was no record of beta radiation treatment in the patient notes, so at follow up the examining doctor did not know which arm of the study the patient belonged to”  Bottom of page 259 top of page 260. We have made the assumption that the patient did not know either although this was not explicitly stated.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	“...follow‐up periods ranged between 3 and 42 months. Three patients only had 3 months follow‐up..” Page 261, first paragraph. However, follow‐up times for each treatment group were not given.
Selective reporting (reporting bias)	Low risk	The main outcome reported in this study was intraocular pressure, as would be expected
Other bias	Low risk	‐