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. 2020 Apr 2;21(7):2474. doi: 10.3390/ijms21072474

Figure 6.

Figure 6

Multi-step mechanism of ligand-dependent AhR transformation involves interplay of hsp90 dissociation and dimerization with ARNT. (A) Proposed transitional mechanism of AhR transformation (details in text). (B). Homology model of the AhR:ARNT dimer [33] with close-ups of the AhR PASA Arg-Cys-rich region (left) and AhR PASB (right). Residues discussed in the text are represented with sticks and labeled.