Table 2.

miRNAs regulating cancer—TECs cross-talk.

miRNA Released by Cancer Cells	Effect on Angiogenesis Progress	Endothelial Target	Reference
miR-9	Pro-angiogenic	SOCS5, JAK-STAT pathway, COL18A1, THBS2, PTCH1, PHD3	[104,105]
miR-494	Pro-angiogenic	PTEN	[96]
miR-146a	Pro-angiogenic	PDGFR, VEGF	[97]
miR-296	Pro-angiogenic	HGS	[98]
miR-130a	Pro-angiogenic	c-MYB	[106]
miR-93	Pro-angiogenic	ITGB8, EPLIN, LATS2	[107,108]
miR-155	Pro-angiogenic	VHL	[109]
miR-132	Pro-angiogenic	P120RasGAP	[110]
miR-204	Anti-angiogenic	VEGF, PDGF, JAK2, HIF-1A	[111]
miR-134	Anti-angiogenic	VEGF-A, VEGFR1	[112]
miR-543	Anti-angiogenic	ANGPT2	[113]
miR-107	Anti-angiogenic	HIF-1B, VEGF-A	[114]
miR-497	Anti-angiogenic	VEGF-A, VEGFR	[115,116]
miR-29b	Anti-angiogenic	MMP2, VEGF-A, PDGF, MMP9, ITGA6, ITGB1, TGFB	[117,118]
miR-200	Anti-angiogenic	IL6, CSCL1	[119]
miR-214	Anti-angiogenic	HDGF	[120]
miR-126	Anti-angiogenic	LRP6, PIK3R2, VEGF-A	[121,122]
miR-622	Anti-angiogenic	VEGFA	[123]
miR-17-92	Pro-angiogenic	TSP1, DKK3	[124,125]
	Anti-angiogenic	EDNRB	[126]
miR-21	Pro-angiogenic	VEGF, VEGFR, HIF-1A	[127]
	Anti-angiogenic	RhoB	[128]
miR-27B	Pro-angiogenic	DLL4/NOTCH	[129]
	Anti-angiogenic	VEGF-C	[130]

Selected miRNAs involved in promoting or repressing angiogenesis (or both) are listed along with their direct or indirect targets. ANGPT2—Angiopoietin 2; c-MYB—MYB transcription factor; COL18A1—Collagen Type XVIII Alpha 1 Chain; CSCL1—C-X-C Motif Chemokine Ligand 1; DKK3—Dickkopf WNT Signaling Pathway Inhibitor 3; DLL4—Delta Like Canonical Notch Ligand 4; EDNRB—Endothelin Receptor Type B; EPLIN—Epithelial Protein Lost In Neoplasm Beta; HDGF—Heparin Binding Growth Factor; HGS—hepatocyte growth factor-regulated tyrosine kinase substrate; HIF1A—Hypoxia Inducible Factor 1 Subunit Alpha; HIF1B—Hypoxia Inducible Factor 1 Subunit Beta; IL6—Interleukin 6; ITGA6—Integrin Subunit Alpha 6; ITGB1—Integrin Subunit Beta 1; ITGB8—Integrin Subunit Beta 8; LATS2—Large Tumor Suppressor Kinase 2; LRP6—LDL Receptor Related Protein 6; MMP2—Matrix Metalloproteinase-2; MMP9—Matrix Metalloproteinase-9; P120RasGAP—P120-Ras GTPase activating protein; PDGF—Platelet-Derived Growth Factor; PDGFR—Platelet Derived Growth Factor Receptor; PHD3—Prolyl-4-hydroxylase domain 3; PIK3R2—Phosphoinositide-3-Kinase Regulatory Subunit 2; PTCH1—Patched 1; PTEN—phosphatase and tensin homolog; RhoB—Ras Homolog Family Member B; SOCS5—Suppressor Of Cytokine Signaling 5; TGFB—Transforming Growth Factor Beta 1; THBS2—Thrombospondin 2; TSP1—Thrombospondin 1; VEGF—Vascular endothelial growth factor; VEGFC—Vascular endothelial growth factor C; VEGFR1—Vascular endothelial growth factor receptor 1; VHL—von Hippel–Lindau Tumor Suppressor.