Jassal 2007.

Clinical features and settings	Clinical features Between 2004 and 2006, 30 patients were prospectively evaluated who underwent both DSE and coronary angiography. This population included 12 patients (5 male, mean age 59 ± 13 years) referred to rule out CAD with normal kidney function (Cr < 2.0 mg/dL) and 18 patients (8 male, mean age 55 ± 12 years) with CKD (Cr > 2.0 mg/dL) on haemodialysis referred for pre‐renal transplant workup. Setting Boniface General Hospital, Manitoba, Canada
Participants	Number: 18 DM: 38% Angina pectoris: percentage not reported Hypertension: 77% Sex: 44% male
Study design	Cross sectional study
Target condition and reference standard(s)	Coronary artery stenosis measured by coronary angiography Criterion for positive test results was ≥ 50% reduction in cross sectional area.
Index and comparator tests	DSE Beta‐adrenergic blocking agents were withdrawn for 24 hours before the study. Dobutamine was infused at doses of 5, 10, 20, 30, and 40 mg/kg/min for 3 minutes each. Images were analysed using the standard16‐segment model
Follow‐up	None reported
Notes	Only data for the 18 patients referred for pre‐renal transplant workup were considered. Sufficient data in published report to create 2 x 2 table
Table of Methodological Quality
Item	Authors' judgement	Description
Representative spectrum? All tests	Yes	Patients who presented for cardiac evaluation before kidney transplantation.
Acceptable reference standard? All tests	Yes	Coronary angiography with a reference standard threshold of ≥ 50% stenosis.
Acceptable delay between tests? All tests	Unclear	Likely to be short delay between tests.
Partial verification avoided? All tests	Yes	All participants who underwent the index test also had the reference standard test.
Differential verification avoided? All tests	Yes	Disease status (CAD) diagnosed by coronary angiography.
Incorporation avoided? All tests	Yes	Disease status (CAD) diagnosed by coronary angiography.
Reference standard results blinded? All tests	Unclear	Not reported.
Index test results blinded? All tests	Unclear	Not reported.
Relevant clinical information? All tests	Yes	Relevant clinical information was provided regarding the performance and analysis of both the index and reference tests.
Uninterpretable results reported? All tests	Yes	No uninterpretable results were present.
Withdrawals explained? All tests	Yes	No withdrawals were reported.