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. 2011 Dec 7;2011(12):CD008691. doi: 10.1002/14651858.CD008691.pub2

Krawczynska 1988.

Clinical features and settings Clinical features
  • 305 patients with ESKD undergoing cardiac assessment prior to kidney transplant


Setting
  • Emory University School of Medicine, Georgia, USA

Participants
  • Number: 46

  • DM: percentage not reported

  • Angina pectoris: percentage not reported

  • Hypertension: percentage not reported

  • Sex: not reported

Study design Cohort study
Target condition and reference standard(s) Coronary artery stenosis measured by coronary angiography
  • Criterion for positive test results was ≥ 50% reduction in cross‐sectional area.

Index and comparator tests Thalium‐201 Cardiac SPECT
  • Stress was induced in 200 patients via exercise, 105 with dipyridamole. Reversible perfusion deficits constituted a positive test.

Follow‐up Postoperative data available for outcomes of death and adverse cardiac events.
Notes Only available in abstract form (presentation).
Table of Methodological Quality
Item Authors' judgement Description
Representative spectrum? 
 All tests Yes Prerenal transplant cardiac assessment. 305 ESKD patients waiting kidney transplantation.
Acceptable reference standard? 
 All tests Yes Coronary angiography with a reference standard threshold ≥ 50% stenosis.
Acceptable delay between tests? 
 All tests Unclear Likely to be short delay between tests.
Partial verification avoided? 
 All tests No 38 patients received both coronary angiography and stress test.
Differential verification avoided? 
 All tests Yes Disease status (CAD) diagnosed by coronary angiography.
Incorporation avoided? 
 All tests Yes Disease status (CAD) diagnosed by coronary angiography.
Reference standard results blinded? 
 All tests Unclear Not stated in abstract.
Index test results blinded? 
 All tests Unclear Not stated in abstract.
Relevant clinical information? 
 All tests Unclear Insufficient clinical information provided about performance and analysis of the index and reference tests.
Uninterpretable results reported? 
 All tests Yes No results were reported to be uninterpretable.
Withdrawals explained? 
 All tests Yes All patients missing from the final analysis were accounted for.