Marwick 1990.

Clinical features and settings	Clinical features ESKD patients undergoing coronary angiography as part of transplant workup with longstanding diabetes, history of chest pain or previous MI, or age > 40 Setting Cleveland Clinic, Ohio, USA
Participants	Number: 45 DM: 51% Angina pectoris or IHD: 33% Hypertension: 81% Sex: 71% male Exclusion criteria Recent angina or MI
Study design	Cohort study
Target condition and reference standard(s)	Coronary artery stenosis measured by coronary angiography Each angiogram was independently assessed by a reviewer blinded to fluorographic results. CAD was defined as presence of ≥ 1 coronary arteries with ≥ 70% diameter stenosis.
Index and comparator tests	Dipyridamole SPECT Thallium Imaging Images were displayed using a semi‐quantitative system with a segmented colour scale. Scans were interpreted by an experienced observer without knowledge of catheterisation results, and were classified into groups with normal perfusion, fixed defect or reversible defect.
Follow‐up	Follow up over 25 ± 14 months.
Notes
Table of Methodological Quality
Item	Authors' judgement	Description
Representative spectrum? All tests	Yes	ESKD patients undergoing cardiac evaluation as part of transplant workup.
Acceptable reference standard? All tests	Yes	Coronary angiography with a reference standard threshold of ≥ 70% stenosis.
Acceptable delay between tests? All tests	Yes	Thallium scanning was performed within a week of coronary angiography.
Partial verification avoided? All tests	Yes	All participants who received an index test received the reference standard test.
Differential verification avoided? All tests	Yes	Disease status (CAD) diagnosed by coronary angiography.
Incorporation avoided? All tests	Yes	Disease status (CAD) diagnosed by coronary angiography.
Reference standard results blinded? All tests	Yes	Author correspondence.
Index test results blinded? All tests	Yes	Author correspondence.
Relevant clinical information? All tests	Yes	Relevant clinical information was provided regarding performance and analysis of the index and reference tests.
Uninterpretable results reported? All tests	Yes	No results were reported to be uninterpretable.
Withdrawals explained? All tests	Yes	No withdrawals were reported.