Rosario 2010.

Clinical features and settings	Clinical features CKD patients in haemodialysis programs referred for kidney coronary angiography as part of a kidney transplant evaluation. The clinical indication for coronary angiography was based on the fact that the patients belonged to the group under high risk for CAD either due to symptoms and/or previous invasive exams that would lead to a suspicion of CVD. Setting Instituto do Coração (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Participants	Number: 97 DM: 38% Angina pectoris or IHD: 29% Hypertension: 90% Sex: 65% male
Study design	Cohort study.
Target condition and reference standard(s)	Coronary artery stenosis measured by coronary angiography CAD defined as presence of ≥ 1 coronary arteries with ≥ 70% diameter stenosis.
Index and comparator tests	Multi‐detector CT exams Performed in 16 and 64‐column detector‐row. Patients’ heart rates during examination = 61.1 ± 6.9 bpm. Patients with rates > 70 bpm on arrival for CT scan received IV beta‐blocker (metoprolol)to achieve 60 bpm, or the maximum dose (15 mg), since the protocol included associated coronary angiotomography acquisition. Calcium score obtained through prospective acquisition, and synchronised to ECG tracing. Images acquired were 3.0 mm thick, and view field was from 200 to 220 mm for chest axial images covering all cardiac area and allowing visualisation of coronary arteries and possible calcification on coronary artery topography. Images were acquired at a diastolic moment that was defined following patient’s heart rate.
Follow‐up	Follow‐up ongoing.
Notes
Table of Methodological Quality
Item	Authors' judgement	Description
Representative spectrum? All tests	Yes	CKD patients already in a haemodialysis program and referred to be submitted to kidney transplant.
Acceptable reference standard? All tests	Yes	Yes, coronary angiography with a reference standard threshold of ≥ 50 and 70% stenosis.
Acceptable delay between tests? All tests	Yes	Time elapsed between Multi‐detector CT and coronary angiography was on average 99.03 days, SD 87.65 days, and median 79 days. Minimum interval was 2 days, and maximum interval was 380 days. Only 2 cases exceeded 1 year, and 16 cases had an interval over 6 months.
Partial verification avoided? All tests	Yes	All participants who received an index test received the reference standard test.
Differential verification avoided? All tests	Yes	This was not an issue in this study. Disease status (CAD) is diagnosed only through coronary angiography.
Incorporation avoided? All tests	Yes	This was not an issue in this study. Disease status (CAD) is diagnosed only through coronary angiography.
Reference standard results blinded? All tests	Yes	An observer experienced in QCA technique and who did not participate in the Multi‐detector CT analysis ‐ also blind and independent.
Index test results blinded? All tests	Unclear	Not reported.
Relevant clinical information? All tests	Yes	Relevant clinical information was provided regarding the performance and analysis of both the index and reference tests.
Uninterpretable results reported? All tests	Yes	No results were reported to be uninterpretable.
Withdrawals explained? All tests	Yes	No withdrawals were present.