Sharples 2004.

Clinical features and settings	Clinical features ESKD patients referred for coronary angiography as part of cardiac work up before kidney transplantation Setting Two inner city renal units in Royal London and St Bartholomew’s Hospital, London, UK
Participants	Number: 18 DM: percentage not reported Angina pectoris: percentage not reported Hypertension: percentage not reported Sex: 50% male Man age: 53.9 years (range 31 to 73 years) Mean time on RRT: 27.4 months (range 4 to 111 months)
Study design	Cross sectional study
Target condition and reference standard(s)	Coronary artery stenosis measured by coronary angiography CAD defined as presence of ≥ 1 coronary arteries with at least 50% stenosis.
Index and comparator tests	EBCT Images were performed with a 100‐ms scanning time and a single slice thickness of 3 mm. 36 to 40 tomographic slices were obtained for each subject during 2 breath‐holding sessions. The degree of coronary artery calcification was calculated by multiplying the area of each calcified lesion by a weighting factor corresponding to the peak pixel intensity for each lesion to yield a lesion‐specific calcification score. The proximal segments of the left main stem, left anterior descending, left circumflex and right coronary arteries were examined.
Follow‐up	None reported.
Notes	Results reported per vessel, not per patient. Insufficient data to construct meaningful 2 x 2 table. Therefore, study did not contribute data to the meta‐analysis.
Table of Methodological Quality
Item	Authors' judgement	Description
Representative spectrum? All tests	Yes	ESKD patients assessed for CAD before kidney transplant.
Acceptable reference standard? All tests	Yes	Coronary angiography with a reference standard threshold of ≥ 75% stenosis.
Acceptable delay between tests? All tests	Unclear	Likely to be short delay between tests.
Partial verification avoided? All tests	Yes	All participants who underwent the index test received the reference standard test.
Differential verification avoided? All tests	Yes	Disease status (CAD) diagnosed by coronary angiography.
Incorporation avoided? All tests	Yes	Disease status (CAD) diagnosed by coronary angiography.
Reference standard results blinded? All tests	Yes	Analysis of the coronary angiograms was performed using a digital analysis system operated by a cardiologist blinded to the calcification score.
Index test results blinded? All tests	Yes	The acquired images were scored with the use of Imatron software by a single radiologist blinded to the clinical or angiographic history of the patient.
Relevant clinical information? All tests	Yes	Relevant clinical information was provided regarding the performance and analysis of both the index and reference tests.
Uninterpretable results reported? All tests	Yes	There were no uninterpretable results.
Withdrawals explained? All tests	Yes	There were no withdrawals.