West 2000.

Clinical features and settings	Clinical features Dialysis‐dependent renal transplant candidates evaluated between 1 January l993 and 1 March l995 were screened for cardiac high‐risk factors (identified as those with diabetes mellitus, previous MI, age 50 years or more cerebral and/or peripheral vascular disease, CHF, class I or II angina (Canadian Cardiovascular Society classification), and dialysis dependency of more than 5 years). Setting Geisinger Medical Center, Danville, Pennsylvannia, USA
Participants	Number: 33 DM: percentage not reported Angina pectoris or IHD: percentage not reported Hypertension: percentage not reported Sex: not reported
Study design	Cohort study
Target condition and reference standard(s)	Coronary artery stenosis measured by coronary angiography CAD was defined as the presence of one or more coronary arteries with 70% or greater diameter stenosis, or greater than 50% in left main coronary artery.
Index and comparator tests	DSE DSE was performed the day after dialysis to avoid hypertensive blood pressure response from volume overload. A standardised DSE protocol was used. DSE findings were graded as negative if normal wall motion was present and positive when: CAD: fixed, inducible, or mixed segmental wall motion abnormalities Cardiomyopathy: diffuse wall motion abnormalities or Primary valvular heart disease: severe aortic stenosis, aortic insufficiency, mitral stenosis, or mitral regurgitation secondary to primary leaflet abnormalities were present
Follow‐up	Patients were followed up for an unspecified time.
Notes
Table of Methodological Quality
Item	Authors' judgement	Description
Representative spectrum? All tests	Yes	ESKD patients undergoing cardiac evaluation as part of transplant workup.
Acceptable reference standard? All tests	Yes	Coronary artery stenosis measured by coronary angiography. CAD defined as the presence of ≥ 1 coronary arteries with ≥ 70% diameter stenosis, or > 50% in left main coronary artery.
Acceptable delay between tests? All tests	Unclear	Likely to be only delay between tests.
Partial verification avoided? All tests	Yes	All participants who underwent the index test received the reference standard test.
Differential verification avoided? All tests	Yes	Disease status (CAD) diagnosed by coronary angiography.
Incorporation avoided? All tests	Yes	Disease status (CAD) diagnosed by coronary angiography.
Reference standard results blinded? All tests	Unclear	Not reported.
Index test results blinded? All tests	Unclear	Not reported.
Relevant clinical information? All tests	Yes	Relevant clinical information was provided regarding the performance and analysis of the index and reference tests.
Uninterpretable results reported? All tests	Yes	There were no uninterpretable results.
Withdrawals explained? All tests	Yes	Nine patients were excluded because of prior coronary angiography (5), class III ± IV angina (3), and refusal to participate in the study (1).