Worthley 2003.

Clinical features and settings	Clinical features ESKD patients with multiple risk factors (> 60 years; HTN; DM; history of smoking; family history of CAD; hypercholesterolaemia) undergoing cardiac evaluation as part of transplant workup Setting North Western Adelaide Health Service, University of Adelaide, Australia
Participants	Number: 40 DM: 78% Angina pectoris or IHD: 18% Hypertension: 98% Sex: 48% male Exclusion criteria Normal coronary angiography within the preceding 2 years; coronary revascularisation within the last 12 months; evidence of previous Q‐wave infarction on ECG at rest; class III to IV angina pectoris at study entry
Study design	Cohort study
Target condition and reference standard(s)	Coronary artery stenosis measured by coronary angiography Angiograms were assessed by 2 cardiologists who were blinded to the perfusion imaging results. A significant coronary stenosis was defined as > 70%
Index and comparator tests	Tachycardic‐stress perfusion imaging All patients underwent induction of tachycardiac stress via treadmill exercise or temporary cardiac pacing. Treadmill exercise was performed using the Bruce protocol, on a symptom‐limited basis. Exercise was deemed adequate if peak heart rate was > 75% of the theoretic maximal values, or if exercise was terminated because of angina pectoris. Pacing was performed in patients unable to attain adequate stress on treadmill testing. Pacing was performed at the time of cardiac catheterisation, but before coronary angiography. Myocardial imaging was achieved by IV injection of technetium‐99m tetrofosmin (400 MBq) 1 minute before termination of tachycardiac stress. Images were acquired on a triple‐headed gamma camera with 180° single‐photon emission CT. The images were assessed by nuclear cardiologists who were blinded to the cardiac catheterisation results.
Follow‐up	Mean follow‐up of 28 ± 10 months.
Notes	Informed consent was obtained before study entry.
Table of Methodological Quality
Item	Authors' judgement	Description
Representative spectrum? All tests	Yes	ESKD patients undergoing cardiac evaluation as part of transplant workup.
Acceptable reference standard? All tests	Yes	Coronary angiography with a reference standard threshold of ≥ 70% stenosis.
Acceptable delay between tests? All tests	Yes	Tests were done at the same time (author correspondence).
Partial verification avoided? All tests	Yes	All participants who underwent the index test received the reference standard test.
Differential verification avoided? All tests	Yes	Disease status (CAD) diagnosed by coronary angiography.
Incorporation avoided? All tests	Yes	Disease status (CAD) diagnosed by coronary angiography.
Reference standard results blinded? All tests	Yes	Angiograms were assessed by 2 cardiologists who were blinded to the perfusion imaging results.
Index test results blinded? All tests	Yes	Images were assessed by nuclear cardiologists who were blinded to the cardiac catheterisation results.
Relevant clinical information? All tests	Yes	Relevant clinical information was provided regarding the performance and analysis of the index and reference tests.
Uninterpretable results reported? All tests	Yes	There were no uninterpretable test results.
Withdrawals explained? All tests	Yes	No withdrawals reported.

bpm: beats per minute; CAD: coronary artery disease; CF: cardiac failure; CHF: congestive heart failure; CIMT: carotid intimal medial thickness; CKD: chronic kidney disease; CVD: cardiovascular disease; DBP: diastolic blood pressure; DM: diabetes mellitus; DSE: dobutamine stress echocardiogram; DSTS: dipyridamole stress thallium scan; EBCT: electron beam computed tomography; ECG: electrocardiogram; ESKD: end‐stage kidney disease; HTN: hypertension; IHD: ischaemic heart disease; IMT: intimal media thickness; IV: intravenous; MI: myocardial infarction; MIBI: methoxyisobutyl isonitrile stress; MPS: myocardial perfusion scintigraphy; QCA: quantitative coronary analysis; RRT: renal replacement therapy; RWM: regional wall motion; SBP: systolic blood pressure; ST: sinus tachycardia; WMA: wall motion abnormality