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. 2020 Mar 31;21(7):2416. doi: 10.3390/ijms21072416

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of CIL on voltage-gated Na⁺ current (I_Na) in GH₃ cells. In this set of whole-cell current recordings, we suspended cells in Ca²⁺-free Tyrode’s solution containing 10 mM tetraethylammonium chloride TEA, and the recording pipette was filled with Cs⁺-containing solution. (A) Superimposed I_Na densities in response to brief membrane depolarization from −80 to 0 mV. The current-density trace labeled a was control, that labeled b or c was recorded in the presence of 3 μM CIL, or 3 μM CIL plus 3 μM A-803467, respectively. The upper part indicates the voltage protocol applied. The density traces shown in the right side depict an expanded record at the left side (indicated in dashed box). (B) Summary bar graph of the effect of CIL, CIL plus A-803467, and CIL plus tefluthrin (Tef) on the peak density of I_Na during brief step depolarization from −80 to 0 mV (mean ± SEM; n = 8–9 for each bar). CIL: 3 μM CIL; A-803467: 3 μM A-803467; Tef: 3 μM tefluthrin. ^*Significantly different from control (p < 0.05).

Effect of CIL on voltage-gated Na⁺ current (I_Na) in GH₃ cells. In this set of whole-cell current recordings, we suspended cells in Ca²⁺-free Tyrode’s solution containing 10 mM tetraethylammonium chloride TEA, and the recording pipette was filled with Cs⁺-containing solution. (A) Superimposed I_Na densities in response to brief membrane depolarization from −80 to 0 mV. The current-density trace labeled a was control, that labeled b or c was recorded in the presence of 3 μM CIL, or 3 μM CIL plus 3 μM A-803467, respectively. The upper part indicates the voltage protocol applied. The density traces shown in the right side depict an expanded record at the left side (indicated in dashed box). (B) Summary bar graph of the effect of CIL, CIL plus A-803467, and CIL plus tefluthrin (Tef) on the peak density of I_Na during brief step depolarization from −80 to 0 mV (mean ± SEM; n = 8–9 for each bar). CIL: 3 μM CIL; A-803467: 3 μM A-803467; Tef: 3 μM tefluthrin. ^*Significantly different from control (p < 0.05).