Table 6.
Glucose/insulin levels, hemodynamic parameters and subcellular activities in control, STZ-induced diabetic and diabetic animals treated with vitamin E.
| Control | Diabetes | Diabetes + Vitamin E | |
|---|---|---|---|
| Plasma glucose (mg/dl) | 151 ± 8 | 487 ± 9 * | 478 ± 9 * |
| Plasma insulin (µU/mL) | 28 ± 2 | 11 ± 1 * | 12 ± 1 * |
| +dP/dt (mmHg/s) | 5722 ± 254 | 4210 ± 145 * | 5450 ± 180 # |
| -dP/dt (mmHg/s) | 5525 ± 129 | 4155 ± 135 * | 5341 ± 182 # |
| Myofibrillar Ca2+ -stimulated ATPase (µmol Pi/mg/h) | 11.6 ± 0.9 | 5.8 ± 0.5 * | 8.4 ± 0.4 # |
| SL Na+-K+-ATPase (µmol Pi/mg/h) | 24.7 ± 6 | 16.1 ± 2.7 * | 23.6 ± 2.9 # |
| SL Na+- Ca2+-exchanger (nmol Ca2+/mg/2 s) | 3.9 ± 0.2 | 2.1 ± 0.2 * | 3.7 ± 0.4 # |
| SR Ca2+-release (nmol Ca2+/mg/3 min) | 20.5 ± 2.1 | 10.2 ± 1.3 * | 19.1 ± 1.8 # |
| SR Ca2+-uptake (nmol Ca2+/mg/min) | 79.5 ± 7.1 | 43.7 ± 4.3 * | 62.8 ± 3.2 *# |
| MDA (nmol/mg tissue lipids) | 4.2 ± 0.3 | 6.9 ± 0.4 * | 4.3 ± 0.5 # |
| Conjugated dienes (nmol/mg tissue lipids) | 39.6 ± 3.2 | 68.3 ± 7.1 * | 46.7 ± 5.4 # |
Values are means ± S.E. of six experiments. Treatment with vitamin E (25 mg/kg/day, i.p.) was started 24 h after inducing diabetes with STZ. * Statistically significantly different from control (p < 0.05); # statistically significantly different from diabetic value. Data taken from our paper: Dhalla et al. 1998 [26].