Table 1.

Effects of potential activators/potentiators of TMEM16A in HT29 cells (endogenous TMEM16A) and HEK293 cells (overexpressed TMEM16A).

Compound	Endogenous		Expressed
	Activation	Potentiation	Activation	Potentiation
Eact	No (50 µM; n = 5)	No (50 µM; n = 5)	Yes (10 µM; n = 5)	Yes (10 µM; n = 5)
GSK1016790A	No (50 µM; n = 5)	No (50 µM; n = 5)
Melittin	Yes (2 µM; n = 5)	Yes (2 µM; n = 5)	Yes (0.5 µM; n = 5)	Yes (0.5 µM; n = 5)
Cinnamaldehyde	No (1 µM; n = 5)	No (1 µM; n = 5)	Yes (1 µM; n = 5)	Yes (0.5 µM; n = 5)
diC8-PIP2-PL	No (50 µM; n = 5)	No (50 µM; n = 5)	Yes (50 µM; n = 5)	Yes (50 µM; n = 5)
CLCA1	No	Yes