Table 2.
The Reactome analysis linked the TBI-regulated targets of miR-124-3p to signal transduction and immunity. The 20 pathways with the most mapped targets are presented.
| Upregulated Targets of miR-124-3p | Downregulated Targets of miR-124-3p | ||||
|---|---|---|---|---|---|
| Pathway | Subpathway | Molecules | Pathway | Subpathway | Molecules |
| S | Signaling by Receptor Tyrosine Kinases | 25 | NS | Neuronal System | 30 |
| S | Signaling by Nuclear Receptors | 16 | DB | Axon guidance | 21 |
| S | ESR-mediated signaling | 13 | NS | Transmission across Chemical Synapses | 18 |
| MP | IRE1alpha activates chaperones | 9 | MC | Muscle contraction | 14 |
| MP | Unfolded Protein Response (UPR) | 9 | MC | Cardiac conduction | 13 |
| MP | XBP1(S) activates chaperone genes | 8 | NS | Neurotransmitter receptors and postsynaptic signal transmission | 12 |
| DB | Semaphorin interactions | 7 | NS | Potassium Channels | 8 |
| DB | Transcriptional regulation of granulopoiesis | 7 | NS | Protein-protein interactions at synapses | 7 |
| S | Extra-nuclear estrogen signaling | 7 | S | Opioid Signaling | 7 |
| S | Signaling by NTRKs | 7 | GE | MECP2 regulates neuronal receptors and channels | 6 |
| TSM | Plasma lipoprotein assembly, remodeling, and clearance | 6 | MC | Phase 0—rapid depolarization | 6 |
| M | Import of palmitoyl-CoA into the mitochondrial matrix | 5 | M | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 6 |
| CD | Apoptotic execution phase | 5 | IS | MyD88 cascade initiated on plasma membrane | 6 |
| D | Diseases associated with glycosaminoglycan metabolism | 5 | IS | Toll Like Receptor 5 (TLR5) Cascade | 6 |
| NS | GABA receptor activation | 5 | IS | Toll Like Receptor 10 [TLR10] Cascade | 6 |
| S | NRAGE signals death through JNK | 5 | GE | Transcriptional Regulation by MECP2 | 6 |
| H | Basigin interactions | 4 | IS | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6 |
| EMO | Laminin interactions | 4 | IS | MyD88 dependent cascade initiated on endosome | 6 |
| GE | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 4 | IS | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6 |
| CD | Apoptotic cleavage of cellular proteins | 4 | IS | Toll Like Receptor 9 (TLR9) Cascade | 6 |
CD, cell death; D, disease; DB, developmental biology; EMO, extracellular matrix organization; GE, gene expression; H, hemostasis; IS, immune system; M, metabolism, MC; muscle contraction; MP, metabolism of proteins; NS, neuronal system; S, signaling; TSM, transport of small molecules.