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Mechanisms of CRISPR/Cas9 and CRISPRi. (a) CRISPR/Cas9 mechanism as a bacterial defence against invading viruses. (b) Using CRISPR/Cas9 to disrupt target genes. (c) Using CRISPRi with dCas9 to block transcription initiation or transcriptional elongation. (d) CRISPRi using a dCas9-KRAB fusion protein to alter the chromatin state of the gene.
