Table 5.

Case-control studies results.

Author/Year	Antihypertensive Medications	UWS (mL/min)	SWS (mL/min)	SPS (mL/min)	Hyposalivation Salivary Flow Rate	Hyposalivation (%)	Xerostomia (%)	Level of Xerostomia (cm)	p Value
Streckfus et al., 1994b, USA [24]	Diuretic (HCTZ)	-	-	CG: 0.695 ± 0.44 HT: 0.685 ± 0.39 HCTZ: 0.422 ± 0.24	Not available	-	-	-	0.02
Nonzee et al., 2012, Thailand [25]	β-Adrenergic blockers (Propanolol, atenolol) Diuretic (HCTZ) ACE inhibitor (Enalapril) Calcium channel blocker (Amlodipine)	-	CG: 1.31 ± 0.34 HT: 0.73 ± 0.30	-	SWS hyposalivation was diagnosed if the color moved 25 mm at 3 min according to Fontana et al.	CG: 5% HT: 57%	CG: 25.5% HT: 50%	CG: 1.53 ± 1.89 HT: 3.32 ± 2.72	0.05
Muñoz et al., 2012, Chile [21]	Diuretics	CG: 1.92 ± 0.40 HT: 0.57 ± 0.29	-	-	Not available	-	-	-	0.13
De la luz et al., 2013, Mexico [17]	Not available	CG: 0.31 ± 0.17 HT: 0.27 ± 0.17	CG: 1.33 ± 0.70 HT: 1.12 ± 0.62	-	UWS < 0.15 mL/min SWS < 0.5 mL/min	-	CG: 12.7% HT: 23.6%		UWS: 0.023 SWS: 0.001 Xerostomia 0.001
Kagawa et al., 2013, Japan [26]	Not available	CG: 0.32 (0.19–0.51) HT: 0.35 (0.23–0.57)	CG: 1.66 (1.18–2.39) HT: 1.53 (1.01–2.07)	-	Not available	-	-	-	UWS: 0.85 SSS: 0.39
Prasanthi et al., 2014 India [11]	Diuretics	CG: 2.16 ± 0.72 HT: 0.88 ± 0.41	CG: 7.90 ± 1.87 HT: 2.71 ± 1.08	-	UWS < 0.3 mL/min SWS < 0.7 mL/min	-	-	-	0.001
Ivanovski et al., 2015, Republic of Macedonia, [22]	Diuretics β-Adrenergic blockers α-Adrenergic blocker Angiotensin converting enzyme inhibitors Calcium channel blocker Heart glycosides Antihypertensives drugs with central effect	CG: 0.6 ± 0.1 HT: 0.3 ± 0.2	-	-	USW < 0.2 mL/min	-	-	-	0.000
Nimma et al., 2016, India [23]	Not available	CG: 2.73 ± 0.68 HT: 2.58 ± 0.37	CG: 3.30 ± 0.70 HT: 3.63 ± 0.65	-		-	-	-	UWS: 0.13 SWS: 0.39

HT: hypertensive patients; CG: normotensive patients; METRO: metropolol; ENA: enalapril; HCTZ: hydrochlorothiazide.