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The number of rats to successfully meet response criteria and total responses completed on a sustained effort task (DRH) at 11 months of age. (A) rTg-DI met a lower response criterion (two responses within 10 s in the R2 condition, four responses within 10 s in the R4 condition, and so on) than WT rats. (B) DRH average responses; rTg-DI made fewer overall responses during the R2 condition than WT rats. ** p < 0.001. Data represent mean + SEM.
