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. 2019 Aug 22;116(6):1186–1198. doi: 10.1093/cvr/cvz216

Figure 4.

Figure 4

Effect of chronic PFT treatment in TH mice on haemodynamics and mRNA levels of genes involved with p53 signalling. (A) OGTT. Wt + vehicle, nmice = 10; TH + vehicle, nmice = 11; TH + PFT, nmice = 10. (B) CFVR. Wt + vehicle, nmice = 8; TH + vehicle, nmice = 9; TH + PFT, nmice = 9. (C) Capillary density. Wt + vehicle, nmice = 5; TH + vehicle, nmice = 5; TH + PFT, nmice = 6. (D) Apoptotic ECs. Wt + vehicle, nmice = 5; TH + vehicle, nmice = 5; TH + PFT, nmice = 6. (E and F) Infarcted area in the AAR (E) and the AAR in the ventricle (F). Nmice = 6 per group. (G) p53 mRNA levels in MCECs. Wt + vehicle, nmice = 8; TH + vehicle, nmice = 8; TH + PFT, nmice = 8. (H) Tnf mRNA levels in MCECs. Wt + vehicle, nmice = 7; TH + vehicle, nmice = 6; TH + PFT, nmice = 6. (I) Bax mRNA levels in MCECs. Wt + vehicle, nmice = 7; TH + vehicle, nmice = 8; TH + PFT, nmice = 7. (J) Bbc3 mRNA levels in MCECs. Wt + vehicle, nmice = 7; TH + vehicle, nmice = 7; TH + PFT, nmice = 7. (K) Casp2 mRNA levels in MCECs. Wt + vehicle, nmice = 7; TH + vehicle, nmice = 6; TH + PFT, nmice = 6. Data are mean ± S.E. *P < 0.05 vs. Wt + vehicle, #P < 0.05 vs. TH + vehicle. Statistical comparison between time-response curves was made by two-way ANOVA with Bonferroni post hoc test. Statistical comparison between three groups was made by one-way ANOVA with Bonferroni post hoc test.