Figure 1.

Amino-acid sequences of interferon (IFN) regulatory factor 1 (IRF1) homologs in vertebrates. The overline indicates the conserved DNA-binding domain (DBD) signature (amino acids (aa) 1–113), which contains six conserved tryptophan residues. It is also called the IRF domain (yellow underlay). Identical (asterisks) and similar (: or ∙) residues identified by the CLUSTAL W program are indicated. The Latin abbreviation and accession numbers are listed in Table S1 (Supplementary Materials).