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An example weekly schedule of the chronic unpredictable stress (CUS) paradigm used in this study
| Monday | Tuesday | Wednesday | Thursday | Friday | Saturday | Sunday | |
|---|---|---|---|---|---|---|---|
| 9 a.m. | Cold Water Swim | Restraint |
Alter light/dark cycle |
Alter light/dark cycle | |||
| 10 a.m. | No Bedding | Water Deprivation | |||||
| 11 a.m. | Cage Tilt | ||||||
| 12 p.m. | |||||||
| 1 p.m. | Wet Bedding | Cage Tilt | |||||
| 2 p.m. | Cold Water Swim | ||||||
| 3 p.m. | Wet Bedding | No Bedding | |||||
| 4 p.m. | Restraint | ||||||
| 5 p.m. | Food Deprivation | Restraint | |||||
| 6 p.m. | Isolation | Isolation |
