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. 2020 Apr 8;21(7):2593. doi: 10.3390/ijms21072593

Figure 3.

Figure 3

Larger window currents in the p.V445M mutant channel in the Chinese hamster ovary (CHO-K1) cells (A) An enlarger view of Figure 2B between −100 and +5 mV. (B) The product of G/Gmax and I/Imax at each voltage from Figure 1B is plotted against the different voltages in the WT and p.V445M mutant channels (*, p < 0.05 compared to the WT). (C) The ratio between the sustained (the average currents between 90 and 95 ms of the pulse) and peak (maximal) transient currents at +40 to −40 mV (sample sweeps in Supplementary data Figure S2) is significantly smaller in the WT channels in comparison with the p.V445M mutant channels (*, p<0.05 between the WT and p.V445M mutant channel). (D) Fast-inactivation kinetics of WT and p.V445M mutant channels. The inactivation time constants were obtained by fitting the decay phase of transient sodium currents (NaT) shown in Figure 2A with a mono-exponential function. Data are expressed as means ± SEM.