Table 3.
KEAP1/NRF2 system.
| Target | Susceptibility/Challenge | Remarkable Feature | Reference PMID |
|---|---|---|---|
| Gene Knockout | |||
| Nuclear factor erythroid 2-related factor 2 (Nrf2) |
Ultraviolet B | Impaired cytoprotection | 18200051 |
| Chemically induced cutaneous carcinogenesis | 11248092 | ||
| Topical imiquimod | Dysregulated innate immunity | 31953037 | |
| Contact hypersensitivity | Outcomes may depend on contexts. | 18325578 | |
| Kelch-like erythroid cell-derived protein with cap´n´collar homology-associated protein 1 (Keap1) |
N/A * | Hyperorthokeratosis with loricrin overexpression and postnatal lethality | 14517554 |
| Transgenic Overexpression: Dominant-Negative NRF2 | |||
| Basal keratinocytes (K14 promoter-driven) |
Chemically induced cutaneous carcinogenesis | Wound healing is not affected | 16648473 |
| Stratum granulosum keratinocytes (Loricrin promoter-driven) |
Epidermal barrier recovery | Loricrin-knockout background can lead to postnatal lethality | 23237955 |
| Transgenic Overexpression: Constitutively Active NRF2 | |||
| Basal keratinocytes (K5 (or K10) promoter-driven) |
ultraviolet B (resistant) | Phenotypes resemble autosomal recessive congenital ichthyosis or chloacne | 20478997 22383093 24503019 |
* Not applicable.