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. 2020 Apr 8;21(7):2575. doi: 10.3390/ijms21072575

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Structures of tested pyrrolo[3,4-d]pyridazinone derivatives: (2a) 3,5,7-trimethyl-6-phenyl-1-[[3-[(4-phenylpiperazin-1-yl)methyl]-2-thioxo-1,3,4-oxadiazol-5-yl] methoxy]pyrrolo[3,4-d]pyridazin-4-one; (2b) 6-butyl-3,5,7-trimethyl-1-[[3-[(4-phenylpiperazin-1-yl)methyl]-2-thioxo-1,3,4-oxadiazol-5-yl] methoxy]pyrrolo[3,4-d]pyridazin-4-one; (3a) 1-[[3-[[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]methyl]-2-thioxo-1,3,4-oxadiazol-5-yl] methoxy]-3,5,7-trimethyl-6-phenyl-pyrrolo[3,4-d]pyridazin-4-one; (3b) 6-butyl-1-[[3-[[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]methyl]-2-thioxo-1,3,4-oxadiazol-5-yl] methoxy]-3,5,7-trimethyl-pyrrolo[3,4-d]pyridazin-4-one.