Table 2.
Perinatal conditions and development of childhood onset IBD.
| Characteristics | Cases (n = 164), n (%) |
Controls (n = 1640), n (%) |
Adj OR (95% CI) |
Fully Adjusted OR (95% CI) |
|---|---|---|---|---|
| Season of birth | ||||
| May–September | 76 (46.4) | 700 (42.7) | 1.16 (0.84–1.60) | 1.19 (0.86–1.65) |
| October-April | 88 (53.7) | 940 (57.3) | 1 | 1 |
| Siblings | ||||
| Yes | 66 (40.2) | 762 (46.5) | 1 | 1 |
| No | 98 (59.8) | 878 (53.5) | 1.29 (0.93–1.79) | 1.21 (0.85–1.72) |
| Singleton/Multiple births | ||||
| 1 | 159 (97.0) | 1607 (98.0) | 1 | 1 |
| ≥2 | 5 (3.1) | 33 (2.0) | 1.54 (0.59–4.03) | 1.44 (0.49–4.18) |
| Birth weight | ||||
| ≥2500 | 154 (93.9) | 1563 (95.3) | 1 | 1 |
| <2500 | 10 (6.1) | 77 (4.7) | 1.31 (0.67–2.57) | 1.12 (0.42–3.00) |
| Gestational age, weeks | ||||
| ≥36 | 156 (95.7) | 1586 (97.1) | 1 | 1 |
| ≤35 | 7 (4.3) | 47 (2.9) | 1.50 (0.67–3.38) | 1.26 (0.40–4.03) |
| Apgar score | ||||
| ≥7 | 154 (93.9) | 1542 (94.1) | 1 | 1 |
| <7 | 10 (6.1) | 96 (5.9) | 1.05 (0.53–2.07) | 0.96 (0.47–1.96) |
| Maternal age, years | ||||
| <25 | 22 (13.4) | 196 (12.0) | 0.97 (0.58–1.62) | 0.97 (0.57–1.63) |
| 25–29 | 64 (39.0) | 547 (33.4) | 1 | 1 |
| 30–34 | 50 (30.5) | 586 (35.7) | 0.72 (0.49–1.07) | 0.76 (0.51–1.14) |
| 35–39 | 22 (113.4) | 273 (16.7) | 0.68 (0.41–1.14) | 0.74 (0.43–1.27) |
| ≥40 | 6 (3.7) | 38 (2.3) | 1.34 (80.54–3.31) | 1.55 (0.61–3.91) |
| Maternal education | ||||
| Primary/middle school | 62 (37.8) | 673 (41.2) | 1 | 1 |
| High school | 86 (52.4) | 765 (46.8) | 1.22 (0.86–1.72) | 1.23 (0.87–1.76) |
| University | 16 (9.8) | 195 (12.0) | 0.89 (0.50–1.58) | 0.96 (0.53–1.76) |
Adj: sex and year of birth. Fully adjusted: sex; year of birth; season of birth; having older siblings; number of births; birth weight; gestational age; Apgar scores at 1 minute; maternal age; and mother’s formal education at the moment of birth. OR: Odds ratio.