Figure 4.

Adenine-induced renal insufficiency is associated with less pronounced inflammation in AhR^−/− mice. (A) Representative hematoxylin and eosin (H&E) staining of kidney sections of mice (WT and AhR^−/−) from the normal diet and adenine diet groups. The yellow arrows point areas of diffuse inflammation, and the red arrows indicate one dilated tubule. TNF-α (B) and PAI-1 (C) mRNA levels were determined in the kidneys of mice (WT and AhR^−/−) obtained from the normal diet (Norm) and adenine diet (Aden) groups. Data are expressed as mean ± SEM, n = 5–7/group; * p < 0.05; ** p < 0.01. Scale bars = 200 μm.