Figure 4.
The effect of ICMD-01 on complete Freund’s adjuvant (CFA)-induced paw inflammation. Mice were injected with ICMD-01 (25, 50 and 100 mg kg−1), vehicle (5% DMSO in saline; control group) orally or dexamethasone (intraperitoneal route) (Dexa; 2 mg kg−1; reference drug) 40 min before CFA (injected at time zero). Paw edema was measured 2, 4, 6 and 24 h after CFA, represented as paw volume variation. Data are expressed as means ± SEMs; n = 6 mice per group. * Significantly different from the control group (p < 0.05). Two-way ANOVA followed by the Bonferroni’s test.