Figure 7.

The effect of ICMD-01 on PGE₂ paw levels during CFA-induced inflammation. Mice were treated orally with ICMD-01 (50 mg kg⁻¹), dexamethasone (intraperitoneal route) (Dexa; 2 mg kg⁻¹; reference drug), or vehicle (5% DMSO in saline; control group) 40 min before the intraplantar injection of CFA (20 μL/paw). The naïve group consisted of mice that did not receive any experimental manipulation. Panels show the paw levels of (prostaglandin E₂ (PGE₂), determined in skin tissues samples 3 h after the CFA injection. The results are expressed as picograms of PGE₂ per milligram of protein. Data are expressed as means ± SEMs; n = 6 mice per group. *** Significantly different from the vehicle group in the same time (p < 0.05); ^# significantly different from the naive group (p < 0.05). ANOVA followed by Tukey´s multiple comparison test.