Table 1.

In silico pharmacokinetic data estimated with SwissADME or pkCSM web services. ^a SwissADME Moriguchi log of octanol-water partition coefficient. ^b SwissADME Ali log of aqueous solubility. ^c SwissADME calculation of Topological PolarSurface Area (TPSA). ^d pkCSM prediction of Caco-2 cell permeability estimation of absorption at human intestinal mucosa. ^e pkCSM prediction of the proportion of compound absorption though the human small intestine. ^f pkCSM prediction of the log of steady state volume of distribution (VDss). ^g pkCSM prediction of compound fraction unbound in plasma (not bound to serum proteins). ^h pkCSM prediction of the log of total drug clearance.

Compound	LogP a	LogS b	TPSA (Å2) c	Caco-2 Permeability (log Papp; log cm/s) d	Int. Abs. (%) e	VDss (log L/kg) f	Fract. Unb.g	Total Clearance (log ml/min/kg) h
ICMD-01	2.40	−3.98	64.92	0.825	91.123	0.252	0.00	0.318