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. 2020 Apr 5;21(7):2532. doi: 10.3390/ijms21072532

Figure 2.

Figure 2

T-cell activation or inhibition is the result of an integrated and sequential intracellular signal cascade after MHC-peptide recognition by TCR. Abbreviations: GITR = Glucocorticoid-Induced TNF Receptor, ICOS = Inducible co-stimulator, OX40 = CD134, TCR = T-Cell Receptor, PD1 = Programmed Death 1, CTLA4 = Cytotoxic T-lymphocyte Antigen-4, LAG3 = Lymphocyte-associated gene 3, TIM3 = Tcell Immunoglobulin and Mucin domain-3, TIGIT = T-cell Immunoglobulin and ITIM domain, VISTA = Vdomain Immunoglobulin Suppressor of T-cell Activation.